Scientific Papers


Read About How Our Technology Has Been Used

Our patented technology has been utilised by scientists for several years now. And part of being a scientist is publishing data. Take a look at some of the scientific papers published to date, which utilised Sphere Fluidics’ picodroplet and microfluidic technology.

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Scientific papers

Scientific Papers Available for Download

Kelley et al. 2018. Rapid Generation of High-Producing Clonal Cell Lines: Using FRET-Based Microfluidic Screening for Analysis, Sorting, Imaging, and Dispensing BioProcess International 2018

Craig 2018. Microfluidics driving innovation and streamlining single cell analysis. Drug Discovery World Summer 2018: 61-66.

Sphere Fluidics 2018. Designing a CRISPR experiment. Gene Editing 101 (2018 Edition). An introduction to Gene Editing: 18-26.

Morf J. et al. 2017. Spatial RNA proximities reveal a bipartite nucelar transciptome and territories of differential density and transcription elongation rates. BioRxiv:

Crawford et al. 2017. Image-based closed-loop feedback for highly mono-dispersed microdroplet production . Scientific Reports 7, Article number: 10545

Salmon et al. 2016. Monitoring early-stage nanoparticle assembly in microdroplets by optical spectroscopy and SERS. Small. Doi:10.1002/smll.201503513


Bakewell et al. 2016. Exploring and Evaluating Micro-environment and Nanoparticle Dielectrophoretic-induced Interactions with Image Analysis Methods. Materials Today: Proceedings, 3(3): 867-874

Liu et al. 2016. High-throughput screening of antibiotic-resistant bacteria in picodroplets. Lab on a Chip, 2016, DOI: 10.1039/C6LC00180G

Abalde-Cela et al. 2015. High-throughput detection of ethanol-producing cyanobacteria in a microdroplet platform. J. R. Soc. Interface 12: 2015.0216

Bakewell et al 2015a. Real-time dielectrophoretic signalling and image quantification methods for evaluating electrokinetic properties of nanoparticles. Electrophoresis. 36(13): 1443–1450

Bakewell et al. 2015. Information processing tools for extracting the electrical properties of nanoparticles. AIP Conf. Proc. 1646: 17-24

Parker, R. M. et al. 2015. Electrostatically directed self-assembly of ultrathin supramolecular polymer microcapsules. Advanced Functional Materials. 25(26): 4091-4100.

Sherwood et al. 2014. Spatial Distributions of Red Blood Cells Significantly Alter Local Haemodynamics. PLOS One 9(6): :e100473

Kruger et al. 2014. Deformability-based red blood cell separation in deterministic lateral displacement devices—A simulation study. Biomicrofluidics 8: 054114

Holmes et al. 2014. Separation of blood cells with differing deformability using deterministic lateral displacement. Interface Focus 4. 20140011

Ma et al. 2013. Monodisperse collagen–gelatin beads as potential platforms for 3D cell culturing. J. Mater. Chem. B, 1: 5128-5136

Shim et al. 2013. Ultrarapid Generation of Femtoliter Microfluidic Droplets for Single-Molecule-Counting Immunoassays. ACS Nano 7(7): 5955-5964

Smith et al. 2013. Sensitive, High Throughput Detection of Proteins in Individual, Surfactant-Stabilized Picoliter Droplets Using Nanoelectrospray Ionization Mass Spectrometry. Analytical Chemistry. 85(8): 3812-3816

Chokkalingam et al. 2013. Probing cellular heterogeneity in cytokine-secreting immune cells using droplet-based microfluidics. Lab Chip 13: 4740-4744

Ma et al. 2012. Fabrication of Microgel Particles with Complex Shape via Selective Polymerization of Aqueous Two-Phase Systems. Small. 8(15): 2356-2360

Use of standards for digital biological information in the design, construction and description of a synthetic biological system – Guide. 2015. PAS 246:2015