Why Choose the Cyto-Mine® Single Cell Analysis System?
There are a number of different techniques that are routinely used in the biopharmaceutical discovery and development workflow, including single cell analysis, sorting, imaging and dispensing into individual wells of microtitre plates. Traditionally, different items of equipment would be required for each technique, resulting in a costly and time-consuming process that uses up valuable lab space and increases risk of sample contamination.
Our Cyto-Mine® technology is the first integrated device to be able to automatically perform all of these crucial techniques in a single compact system. This high-throughput instrument uses picodroplet technology and microfluidics to process upto 40 million heterogeneous mammalian cells within several hours. Each cell is encapsulated in a picodroplet containing growth media, which acts as a bioreactor to compartmentalise the cell and let it grow; eventually trapping secreted molecules such as antibodies. The unique workflow enables selective screening of single cells to find rare lead candidates.
The Applications of Cyto-Mine® for Single Cell Analysis
There are three main application modes for the Cyto-Mine® system:
- Monoclonality assurance mode – reliably sort single cells into individual wells of 96- or 384-well microtitre plates.
- Direct assay mode – sort rare clones at high throughput and ensure the most relevant clones are flagged for downstream analysis.
- Stability test mode – identify unstable clones early so that they can be eliminated from the analysis or inform you of “genetic drift” in a cell population.
Why Choose Our Technology?
Because we have a competitive advantage. Our technology is not only more cost-effective, both in terms of initial outlay and ongoing costs, but it delivers quality results.
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