Single cells

Encapsulating Biology
Transforming Discovery

Our novel research and integrated instruments and collaborative research services enable the rapid engineering, screening and characterisation of single cells and their biological products. These cells are subsequently useful in research, biotherapeutics, bioproduction, cell therapy, drug discovery and diagnostics.

If you’re searching for rare and valuable variants within large cell populations, or wish to engineer them, we can help you do it faster, more cost-effectively and with a greater chance of success.

The Fast and Effective Engineering and Screening of Single Cells for Research and Development Applications

With flexible, future-proofed technologies we boost assay throughput and sensitivity, reduce consumable usage and optimise discovery, development and bioproduction across a broad range of applications.

Biopharmaceuticals and antibody production

Biopharmaceutical Discovery and Development

Increase the throughput and speed of your R&D pipeline. Better characterise biotherapeutic products. Carry out effective cell sorting and retrieval – and find those ‘rare’ variants.

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Synthetic biology

Bioproduction and Synthetic Biology

Rapidly screen large libraries to sort through diverse populations of bacteria, yeast, hybridomas and transformed cells to find the best clones with the relevant phenotype.

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Cell therapy engineering, analysis and isolation

Cell Therapy Engineering and Genome Editing

Use primary cells or precision engineer or transform, analyse and select cells for therapeutic applications, such as using engineered T-Cells for cell therapy, or novel research studies.

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Drug discovery and biotherapeutics

Single Cell Disease Research

Carry out in-depth studies into infectious diseases, cancer and autoimmune disease through the effective compartmentalisation and analysis of single cells from disease-related samples.

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Metagenomic analyses


Use our systems to carry out comprehensive metagenomic analyses that probe deeper into complex conditions, such as metabolic disorders and poorly defined diseases.

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Single cell diagnostics

Single Cell Diagnostics and Prognostics

Our technology is an effective tool for purifying complex clinical samples and analysing single cells to improve patient diagnosis and better predict prognosis.

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Our technology makes it possible to screen billions of cells and provides you with the best chance of finding that rare and valuable variant.

How do we do this? With microfluidic technology that allows the ultra-high throughput analysis of isolated single cells in miniaturised (pL to nL) volumes, picodroplets.

We offer a number of systems, from fully automated and integrated solutions designed for ‘plug and play’ use, through to flexible research instruments and customised research services for use in laboratories with more specialised needs. Our range of cost-effective consumables is specifically designed to work harmoniously with our instruments, providing significant time, cost and energy savings when used together.

Our technology and expertise is applied with our novel workflows to aid the discovery and development of therapeutics from single cells. Whether it’s for short research projects, technology development programs or partnerships, we provide a range of specialist collaborative services to suit your needs. Together we can reduce the cost and complexity of your research, and increase the speed of your discoveries.

Sphere Fluidics collaborates with Peak Analysis and Automation to increase throughput in antibody discovery and cell line development



PAA’s S-LAB micro-plate handling capability will be integrated with the Sphere Fluidics’ Cyto-Mine® Single Cell Analysis System

Cambridge and Farnborough, UK, 15 January 2019: Sphere Fluidics, a company commercializing single cell analysis systems underpinned by its patented picodroplet technology, and Peak Analysis and Automation (PAA), a leader in the industry for the design and manufacture of automated laboratory equipment, will collaborate to offer automated micro-plate handling capabilities for single cell analysis. PAA’s S-LAB™ plate handler will be integrated with Sphere Fluidics’ Cyto-Mine® Single Cell Analysis System to help increase throughput in antibody discovery and cell line development.

Sphere Fluidics’ Cyto-Mine is an automated platform which combines single cell screening, sorting, isolation and clone verification, alleviating the need for separate instruments. Its application programming interface (API), introduced as part of the updated Cyto-Mine Studio Software Suite in 2018, enables easy communication with PAA’s innovative S-LAB automated plate handler. The integration of micro-plate handling with the Cyto-Mine will help to reduce hands-on intervention to further streamline biopharmaceutical workflows.

Dr Frank Craig, CEO, Sphere Fluidics, commented:Our Cyto-Mine® is compatible with 96- and 384-well microtiter plates, providing a high-throughput platform for single cell analysis. By combining this with the easy-to-use automated plate handler from Peak Analysis and Automation we will be able to offer improved throughput capabilities to help reduce timelines in biotherapeutic discovery and cell-line development.”

Dr Malcolm Crook, Technical Director, Peak Analysis and Automation, said: Our small, affordable plate handler with the reliability of a robotic arm will offer users of Sphere Fluidics’ award-winning Cyto-Mine® system a simple and flexible solution to further improve workflows and reduce costs associated with a more labor-intensive approach.”

Cyto-Mine® will be on display in Washington, DC at SLAS 2019 from 2nd to 6th February 2019 (Booth #1655 and #1429).

For further information about Sphere Fluidics and Cyto-Mine®, please visit:

For further information about PAA’s lab automation systems, please visit:


S-LAB™ automated plate handler (left) and Cyto-Mine (right)

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