Phage, Microbial and Other Display Applications

How Our Technology Improves the Quality of Display Experiments

Phage, microbial and other display methods are very useful tools in protein engineering, as well as when screening antibodies as drugs for use in human therapies. If you use these in your research, then you’ve probably faced the problem where the phage grow at different speeds. This natural growth pattern can result in fast-growing phage variants replicating and outgrowing slow-growing ones by as much as 100 to 1, leading to a loss in library diversity. The lower the diversity, the less likely that you will find as many rare and valuable variants.

Our picodroplet technology can help you achieve a better representation of your library by separating each variant into their own compartment, allowing each to grow at its own pace to saturation, without needing to compete with neighbouring variants.

Bacteria

The Unique Benefits of Our Systems for Display Techniques

By encapsulating each individual phage in a picodroplet, you will reduce library bias towards rapidly-growing phages. This competition-free environment preserves phages for downstream analysis that would otherwise be lost, resulting in greater genetic diversity of your library.

Normally, display techniques are time-consuming and laborious processes, especially when done manually. However, by using our picodroplet technology, you can automate the entire process on a biochip. This approach has many applications in biopharmaceutical discovery, for example, when using phage or microbial display techniques to further optimise lead antibodies.

Single cell phage display