Cancer Cell Disease Research
How Our Technology Improves Cancer Research
Tumour progression is the result of mutations that cause abnormal clonal expansions, leading to these cells spreading and diversifying. The cells in a tumour usually aren’t all the same, and can vary in terms of size, protein levels, gene expression and even their ability to cause metastasis. This can make it very difficult to understand which cells are driving tumour growth and diversification, as well as which factors are interacting with each another and the surrounding environment to facilitate these processes. As you might imagine, this diversity and complexity can make it difficult to identify the best target for developing a treatment.
Here at Sphere Fluidics, we’ve taken these common challenges into account and developed a unique platform that will help you screen single cells. This will enable you to study the gene and protein expression profiles of individual cancer cells, and find new regulatory pathways or previously undetected clones for further study.
The Unique Benefits of Our Systems for Cancer Research
Circulating tumour cells are present in roughly one in a million white blood cells or one in one billion red blood cells. Traditionally, isolating cancerous cells from a heterogeneous cell population would be extremely time-consuming and technically challenging.
Fortunately, our research instruments are capable of the high-throughput analysis of single cells. Our novel technology uses picodroplets to encapsulate purified white blood cells from clinical samples for high-throughput analysis. These isolated single tumour cells can then be further characterised and analysed to facilitate the development and refinement of personalised medicines for the treatment of cancer patients. Our technology also facilitates single cell proteomic analysis, and their isolation for downstream genomic and epigenomic analysis, to enable profiling of populations of cancer cells derived from liquid biopsies.
What’s more, our systems can help you do all of this faster and more cost-effectively than any other approach currently available to researchers.